Noncovalent hybrid of Pd(phen)(OAc)2 and st-DNA for enantioselective hydroamination of β-nitrostyrene with methoxyamine

We developed a novel Pd-catalysed enantioselective synthesis of C-N bond in the chiral scaffold of DNA. The non-covalently linked Pd(phen)(OAc)2 to st-DNA catalysed the Markonicov hydroamination of methoxyamine into β-nitrostyrene for the first time with >75% enantiomeric excess (ee) and excellent atom economy in aqueous buffer (pH 7.4), room temperature.