Craniosynostosis: clinical and fundamental aspects
2000
textabstractPrior to the discovery of the genetic background of craniosynostosis,
its classification was purely based on clinical features. This
classification system did however have its pitfalls which became more
obvious after comparing it with the detected genetic mutations.
Because this classification has been the basis for clinical practice for
years and still is applied world wide, this chapter will begin by giving
a historical and clinical view on craniosynostosis before discussing the
genetic aspects.
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