Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease

While motor neuron diseases are currently incurable, induced pluripotent stem cell research has uncoveredsome disease-relevant phenotypes. We will discuss strategies to model different aspects of motor neuron dis-ease and the specific neurons involved in the disease. We will then describe recent progress to investigatecommon forms of motor neuron disease: amyotrophic lateral sclerosis, hereditary spastic paraplegia andspinal muscular atrophy.