Synthesis of sialoconjugate

PURPOSE: To provide a method for mass-synthesizing an α2,3-sialylated conjugate by allowing a trans-sialidase to act under a specific condition. CONSTITUTION: A trans-sialidase is allowed to react with SAα2-R 1 (R 1 and R 2 are each independently a sugar, a glycolipid, a glycopeptide, a noncyclic or aliphatic hydrocarbon or an aryl residue; SA is a naturally formed sialic acid or a derivative thereof) as a donor in the presence of Ga1β1-R 2 as a receptor in the method for mass-synthesizing α2,3-sialylated conjugates. The oligosaccharide of the formula SAα2-3Ga1β1-R 2 is effectively mass-synthesized. COPYRIGHT: (C)1994,JPO