Cu‐Catalyzed Coupling of O‐Acyl Oximes with Isatins: Domino Rearrangement Strategy for Direct Access to Quinoline‐4‐Carboxamides by C–N Bond Cleavage
2018
A mild domino rearrangement strategy for the direct access to substituted quinoline‐4‐carboxamides has been developed. This copper‐catalyzed coupling reaction of O‐acyl oximes with isatins in the presence of molecular oxygen as the sole oxidizing agent proceeds through a ring expansion of the isatins through cleavage of the two CN bonds
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