Milbemycin analogue and preparation method and application thereof

The invention relates to milbemycin analogues, namely a compound 1 and a compound 2. Two new milbemycin analogues have stronger insecticidal activity compared with the conventional industrial milbemycins A3 and A4 and have very good preventive and therapeutic effect on plutella xylostella, aphid and red spiders. The invention further relates to a preparation method of the compound 1 and the compound 2. The method comprises the following steps: streptomyces avermitilis strain NEAU1069 is conducted with fermental cultivation to obtain a fermental fluid containing the compound 1 and the compound 2, and the compound 1 and the compound 2 are separated from the fermental fluid. The invention further relates to a pesticide combination which contains the compound 1 and/or the compound 2 and the compound 1 and/or compound 2 used for preparing the pesticide combination used for guarding against crop diseases and pests.