Synthesis, characterization and antimicrobial studies of novel compound andits metal complexes derived from nicotinic acid

A Schiff base of Nicotinic acid hydrazide was designed with the aim to develop novel antimicrobial agent of synthetic origin having broad spectrum of activity and high potency. The Schiff base (E)-N'-(thiophen-2- ylmethylene)nicotinohydrazide (TCNH), formed by the condensation of nicotinic acid hydrazide and thiophene-2- carboxaldehyde, was treated with Metal chlorides [Mn(II),Co(II),Cu(II) and Zn(II)] to prepare the complexes of TCNH. The chemical structure of TCNH was established by means of elemental, UV, IR, 1H NMR, 13C NMR and Mass Spectral studies. The metal complexes were characterized by elemental, UV, IR, Cyclic Voltammetry and ESR spectral studies. Further, TCNH and its metal complexes were tested against three pathogenic micro organism Staphylococcus aureus (S.aureus), Escherichia coli (E.coli) and Aspergillus Niger (A.niger). All the metal Complexes exhibit higher antibacterial activities than the free ligand.