Chronobiology of Human Bone Marrow

Bone marrow is the production site for all types of blood cells, which are released into the peripheral blood according to the needs of the body, mediated through different feedback mechanisms. The production occurs as a combination of cell proliferation and gradual maturation, until the end stage is reached with a population of mature cells that can exert their specialized functions but are no longer capable of cell proliferation [1]. It takes approximately 14 days from immature stem cells starting proliferation until mature cells result [2].