Association of LEP and ADIPOQ common variants with colorectal cancer in Mexican patients.

Abstract. Leptin and adiponectin are cytokines produced by adipose tissue with opposite effects on tumor growth: the formerstimulate whereas the latter inhibit it. The objective was to analyze the association of LEP A19G and ADIPOQ +45 T/G and+276 G/T polymorphisms in Mexican patients with colorectal cancer (CRC). 68 unrelated patients with CRC (study group) and102 blood donors (control group); all subjects were Mestizos from western Mexico. The polymorphisms were established byPCR-RFLP on DNA samples obtained from peripheral blood. The LEP A19G polymorphism showed significant differencesbetween CRC patients and control group (p =0.01 for G/A genotype and p = 0.02 for the recessive model G/G + G/A); yet, inthe analysis stratified by gender, this difference remained significant only in males. The ADIPOQ polymorphisms did not shownany significant differences. Our results suggest that the A19G LEP polymorphism is associated with CRC in Mexican patients.Keywords: Leptin, adiponectin, colorectal cancer, polymorphism