Investigation of Changes in the Microviscosity of the Erythrocyte Membranes and Glutathione in the Plasma of Animals with an Experimental Pathology Type Alzheimer’s Diseases

Changes in the microviscosity of the lipid and protein components of the membrane, lipid peroxidation parameters in erythrocytes based on the level of malonyldialdehyde (MDA), and redox status of the glutathione system in the plasma are studied on NMR1 mice in the experimental model of an Alzheimer’s disease (AD)-like pathology from 2 weeks to 12 months after the operation. It is found that the induction of significant levels of lipid peroxidation measured as an increase in the level of MDA, together with AD-like symptoms, occurs only after the significant depletion of reduced glutathione (GSH), increase in oxidized glutathione (GSSG), and decrease in the thiol/disulfate ratio ([GSH]/[GSSG]) in the plasma of ageing mice.