Cardiac Lesions in the Frog Induced by Adrenaline

: Adrenaline (A) causes gross lesions of the ventricular wall in frogs living both at 12° and 25°. At 12° the sensitivity of the heart to A is higher than at 25°. Single or multiple ventricular aneurysm, provoked by A could not be prevented by propranolol. The resistance of the myocardium towards cyanide anoxia is lowered after A especially at 25°. In preliminary experiments with noradrenaline the same cardiotoxic effects are observed.