Six new compounds from the flowers of Chrysanthemum morifolium and their biological activities

Abstract Flower of Chrysanthemum morifolium is widely used in China and Japan as a folk medicine in treatment of many diseases. However, its active compounds remain largely unknown. In the present work, we have isolated, purified and characterized six new compounds ( 1 – 6 ), including two new arylnaphthalene lignans and four new phenolic glycosides, together with eight known compounds ( 7 – 14 ), from the flower of C. morifolium . Their structures and absolute configurations were elucidated in detail using 1D and 2D NMR, UV, IR, ORD, HRESIMS and ECD spectrometric data. In addition, compounds 1 – 3 possessed the significant neuroprotective activity against hydrogen peroxide-induced neurotoxicity in human neuroblastoma SH-SY5Y cells.