A Novel 6-(2-methyl-2-alkylsubstituted-2H-chromen-6-yl)-amine Derivatives and Pharmacophore Model as 5-Lipoxygenase Inhibitors

E-mail: nskang@cnu.ac.krReceived July 6, 2011, Accepted August 8, 2011Key Words : 6-(2-Methyl-2-alkylsubstituted-2H-chromen-6-yl)-amine derivatives, 5-Lipoxygenase(5-LO),Drug-like core skeleton, Pharmacophore The recent discovery of the 5-lipoxygenase (5-LO) inhibitorhas attracted strong research attention as it has the potentialto offer a magic bullet treatment for inflammation.