Platinum-Catalysed Allylic Alkylation: Reactivity, Enantioselectivity, and Regioselectivity

Platinum complexes of phosphino-oxazoline ligands catalyse allylic alkylations with good yields and enantioselectivity (see diagram), but show interesting differences compared to similar palladium complexes. Highly regioselective alkylation of mono(alkyl)-substituted allylic acetates is observed when Cy3P is used as ligand.