Flexible Fitting of PROTAC Concentration-Response Curves with Changepoint Gaussian Processes.

Elizaveta Semenova,Maria Luisa Guerriero,Bairu Zhang,Andreas K. Hock,Philip Hopcroft,Ganesh Kadamur,Avid M. Afzal,Stanley E. Lazic

Flexible Fitting of PROTAC Concentration-Response Curves with Changepoint Gaussian Processes.

2021

Elizaveta Semenova
Maria Luisa Guerriero
Bairu Zhang
Andreas K. Hock
Philip Hopcroft
Ganesh Kadamur
Avid M. Afzal
Stanley E. Lazic

A proteolysis-targeting chimera (PROTAC) is a new technology that marks proteins for degradation in a highly specific manner. During screening, PROTAC compounds are tested in concentration–response...

Keywords:

Degradation (geology)
Gaussian process
Biological system
Bayesian inference
Physics
Concentration Response

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