Pharmacokinetic study of iguratimod in rats

Objective To study the pharmacokinetics of iguratimod in rats. Methods The concentration of iguratirnod in the samples was determined by HPLC method. The pharmacokineties parameters were calculated with DAS softwrare. Results The main pharmacokineties parameters of normal group(6mg/kg) were as follows:t1/2Ke: 3.56h, tpeak: 4.00h, Cmax : 8.87μg/ml, AUC0.24 : 74.76μg· ml-1·h-1. The main pharmacokineties parameters of three model groups(3,6,12mg/kg) were as follows: t1/2Ke: 4.54,3.20,3.17h, tpcak:3.83,3.83,4.67h, Cmax:3.84, 8.31,12.69μg/ml, AUC0.24 :40.21,76. 72,117.06μg·ml-1·h-1. Except Cmax and AUC, no significant differences were found between the three model groups. And the differences between normal group and model group were not significant. Conclusion The pharmacokinetics of rats ks fit to one-compartment model. Key words: Iguratimod;  Pharmacokinetics;  Arthritis, experimental;  Mus