Isolation of monoclonal antibodies from anti-synthetase syndrome patients and affinity maturation by recombination of independent somatic variants.

Luke Burman,Yeeting E. Chong,Sherie Duncan,Anders Klaus,Kaitlyn Rauch,Kristina Hamel,Karine Hervé,Stephanie Pfaffen,David W. Collins,Kevin A. Heyries,Leslie A. Nangle,Carl L. Hansen,David J. King

Isolation of monoclonal antibodies from anti-synthetase syndrome patients and affinity maturation by recombination of independent somatic variants.

2020

Luke Burman
Yeeting E. Chong
Sherie Duncan
Anders Klaus
Kaitlyn Rauch
Kristina Hamel
Karine Hervé
Stephanie Pfaffen
David W. Collins
Kevin A. Heyries
Leslie A. Nangle
Carl L. Hansen
David J. King

The autoimmune disease known as Jo-1 positive anti-synthetase syndrome (ASS) is characterized by circulating antibody titers to histidyl-tRNA synthetase (HARS), which may play a role in modulating ...

Keywords:

Somatic cell
HARS
Affinity maturation
Antibody titer
Antibody
Autoimmune disease
Monoclonal antibody
Aminoacyl tRNA synthetase
Biology
Molecular biology

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