Synthesis, characterization and antiproliferative activity of mixed ligand complexes of Cu2+ and Co2+ with lapachol

Abstract Mixed ligand complexes [Cu(phen)(Lap) 2 ] ( 1 ) and [Co(dppeO)(Lap) 2 ] ( 2 ) were synthesized from the reaction of lapachol (Lap) with [Cu(phen)Cl 2 ] or [Co(dppe)Cl 2 ] in the presence of Et 3 N. Complexes ( 1 ) and ( 2 ) were fully characterized by X-ray crystallography, elemental analyses, and infrared spectroscopy. Antiproliferative activities of complexes ( 1 ) and ( 2 ) against several tumor cell lines were also determined alongside those of [Cu(Lap) 2 (EtOH) 2 ] ( 3 ) and [Co(Lap) 2 (EtOH) 2 ] ( 4 ).