Zn2+/MCM-41 Catalyzed Biginelli Reaction of Heteroaryl Aldehydes and Evaluation of the Antimicrobial Activity and Cytotoxicity of the Pyrimidone Products.

The three component Biginelli condensation of various aryl aldehydes, 1,3-dicarbonyls and urea was investigated in the presence of free or MCM-41 supported ZnNO3. The pyrimidone products, which were obtained under solvent-free conditions, were evaluated for antibacterial and antifungal activities as well as their cytotoxicities.