MP08-20 AN EVALUATION OF MULTIPLE-DRUG RESISTANCE (MDR) BACTERIA IN PATIENTS WITH URINARY STONE DISEASE: DATA FROM A HIGH-VOLUME STONE MANAGEMENT CENTER

INTRODUCTION AND OBJECTIVES:MDR bacteria can lead to intractable infection in patients with urolithiasis and increase mortality rate as well as medical costs. Thus it is important for clinicians to establish evidence-based strategies of antibiotics use. This study aims to evaluate the prevalence of MDR bacteria in a high volume stone management center and investigate the resistance patterns.METHODS:A retrospective study was performed among patients diagnosed with urolithiasis in Beijing Tsinghua Changgung Hospital from 2014 December to 2018 May. Only patients who had positive urinary culture with a bacteria growth >10^5 colony-forming units and drug-sensitivity tests were included. MDR bacteria were defined as any bacteria that gain resistance to at least one agent in ≥3 classes of antibiotics.RESULTS:1655 patients with urolithiasis were analyzed, among which 357 patients had positive urinary culture results, yielding 457 isolates of 45 kinds. The E.coli remains the most common with a prevalence of 29.3%,...