In Vivo Monitoring of Circadian Output in Clock Mutant Mice

It is well established that the suprachiasmatic nucleus (SCN) is the master circadian pacemaker in behavior and vice versa locomotor activity rhythm reflect SCN function as well. In this paper, we reported functional correlations between the SCN and locomotor activity in circadian systems by using direct read out of neuronal activity in the SCN and Clock mutant mice as effective tools. Further behavioral analysis revealed a possibility of unknown circadian oscillatory mechanism.