Triplet Excimers of Fluoroquinolones in Aqueous Media
2012
Generation of triplet eximers of 6-fluoro-7-piperazinyl-quinolone-3-carboxylic acids (FQs) have been detected in aqueous media using laser flash photolysis (LFP). These transient species (SS) are generated by self-quenching reactions of FQ triplet excited states such as pefloxacin (PFX), norfloxacin (NFX), the N-acetylated form of NFX (ANFX), and its methyl ester (EANFX) with their ground states. In this context, self-quenching rate constants in the range of (1–7) × 108 M–1 s–1 were determined. The triplet excimers show transient absorption spectra with λmax ca. 710 nm for SSNFX, 740 nm for SSPFX, and 620 nm for SSANFX and EANFX, which are red-shifted with respect to their predecessors triplet excited states. These excimers can be also observed in the presence of phosphate buffer (PB). Experiments performed with NFX and ANFX at different PB concentrations showed that deprotonation processes are not involved in the generation of SS. The triplet multiplicity of the FQ excimers was confirmed by energy transf...
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