Effect of modular conjugation strategy for N-acetylgalactosamine-targeted antisense oligonucleotides

Tsuyoshi Yamamoto,Motoki Sawamura,Chisato Terada,Koki Kashiwada,Fumito Wada,Asako Yamayoshi,Satoshi Obika,Mariko Harada-Shiba

Effect of modular conjugation strategy for N-acetylgalactosamine-targeted antisense oligonucleotides

2019

Tsuyoshi Yamamoto
Motoki Sawamura
Chisato Terada
Koki Kashiwada
Fumito Wada
Asako Yamayoshi
Satoshi Obika
Mariko Harada-Shiba

AbstractThe asialoglycoprotein receptor (ASGPr) and N-acetylgalactosamine (GalNAc) is one of the most reliable receptor-ligand combinations for delivering antisense oligonucleotides (ASOs) to the l...

Keywords:

Chemistry
N-Acetylgalactosamine
Biochemistry
Oligonucleotide
Sense (molecular biology)
antisense oligonucleotides
Asialoglycoprotein receptor
Acetylgalactosamine

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