Regulation of axon regeneration by the RNA repair and splicing pathway

In this study, the authors show that the RNA repair and splicing pathway regulates axon regeneration in the nervous system of Drosophila. Rtca, a RNA cyclase, is a potent inhibitor of CNS axon regeneration, whereas Archease, a RNA splicing cofactor, functions downstream of Rtca as a pro-regeneration factor. Together, they modify the splicing of Xbp1 in the regulation of axon regeneration.