Specific cardiolipin–SecY interactions are required for proton-motive force stimulation of protein secretion

ACKNOWLEDGMENTS: We thank Audrey Solgadi for mass spectrometry analysis at L’Institut Paris Saclay d’Innovation Therapeutique (IPSIT) and Mikhail Bogdanov for fruitful discussions. This work was funded by the Biotechnology and Biological Sciences Research Council (Grants BB/M003604/1, BB/I008675/1, and BB/N015126/1) and the Wellcome Trust (Grants 104632 and 109854/Z/15/Z). The mass spectrometry work was supported by the Centre National de la Recherche Scientifique, INSERM (Grant “DYNAMO,” ANR-11- LABEX-0011-01 to M.C.) and the Region Ile de France for cofunding the Le Service d’Analyse des Medicaments et Metabolites Mass Spectrometry Facility at IPSIT. E.P. is the recipient of an Imperial College London Institute of Chemical Biology Engineering and Physical Sciences Research Council (EPSRC) Centre for Doctoral Training studentship. This work was carried out using the computational facilities of the Advanced Computing Research Centre, University of Bristol. Additional simulations were carried out using Edinburgh ParallelComputing Centre’s Cirrus and the ARCHER UK National Supercomputing Service (www.archer.ac.uk), provided by HECBioSim, supported by the EPSRC.