Antitumor effect of hydrochloride 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3,3-diphenyl-propyl ester

AIM: To study the inhibition effects of the hydrochloride 4 methyl piperazine 1 carbodithioc acid 3 cyano 3,3 diphenyl propyl ester (Hyd) on the growth of transplant carcinoma in mice. METHODS: The growth of tumor was observed by models of transplant tumor in mice. RESULTS: The inhibition rates of Hyd against tumor growth of S 180 and H 22 implanted human gastric carcinoma were 46.4 %- 59.6 %, 39.3 %- 51.6 % and 18.1 %- 59.0 %, respectively in nude mice. CONCLUSION: Hyd can inhibit the growth of transplanted hepatocyte carcinoma 22, sarcoma 180 in mice, and implanted human gastric carcinoma in mice and nude mice.