광열치료의 열 투여량에 따른 세포 자멸사에 대한 수치적 연구

2018 
Photothermal therapy(PTT) is a therapy for selective ablation of the tumor by using a photothermal effect. However, in spite of using the photothermal effect, which is one of the fields of heat transfer, the research on heat transfer for photothermal therapy is insufficient. In photothermal therapy, GNPs (gold nanoparticles) are used as a photothermal enhancer to selective ablation of tumor. At this time, since the photothermal effect are different depending on the characteristics of the GNPs, and thermal and optical conditions of NIR laser, it is important to find an optimal condition suitable for selective ablation for effective photothermal therapy. In previous photothermal therapy studies, the temperature distribution in tumor tissues has been studied qualitatively. However, the correlation between the death of tumor tissue and thermal and optical conditions of NIR laser has not been quantitatively studied in terms of heat transfer. Therefore, in this study, the conditions (e.g. intensity, beam radius) of the lasers satisfying the apoptosis temperature (43℃ ~ 50℃ , which can effectively ablate tumors) were obtained for various sizes of tumor (width: 2mm ~ 10mm, depth: 0.5mm ~ 4.5mm) using numerical analysis. And quantitative analysis of the apoptosis rate of tumor tissue according to the thermal and optical conditions of photothermal therapy was performed.
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