CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population.

ObjectiveCYP2C8 is known to metabolize various drugs including an anticancer drug paclitaxel. Although large interindividual differences in CYP2C8 enzymatic activity and several nonsynonymous variations were reported, neither haplotype structures nor their associations with pharmacokinetic parameter