Metabolites from the endophytic fungus Cylindrocarpon sp. isolated from tropical plant Sapium ellipticum

Abstract Three new polyketides, cylindrocarpones A−C ( 1 – 3 ), two new pyridone alkaloids, cylindrocarpyridones A−B ( 5 – 6 ), a new pyrone cylindropyrone ( 7 ), together with seven know compounds were isolated from the endophytic fungus, Cylindrocarpon sp., obtained from the tropical plant Sapium ellipticum . The structures of the new compounds were elucidated by extensive analysis of their spectroscopic data (1D and 2D NMR, HRESIMS). The absolute configuration of 19- O -methyl-pyrrocidine B ( 13 ) was confirmed by X-ray analysis. All isolated compounds were screened for their cytotoxic and antibacterial activities. Pyrrocidine A ( 12 ) exhibited potent cytotoxicity against the human ovarian cancer cell line A2780 with an IC 50 value of 1.7 μM. 19- O -Methyl-pyrrocidine B ( 13 ) showed moderate antibacterial activity against S. aureus ATCC25923 and ATCC700699 with MIC values of 50 and 25 μM, respectively.