Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT6 antagonists
2011
As part of our efforts to develop agents for cognitive enhancement, we have been focused on the 5-HT 6 receptor in order to identify potent and selective ligands for this purpose. Herein we report the identification of a novel series of 3-sulfonylindazole derivatives with acyclic amino side chains as potent and selective 5-HT 6 antagonists. The synthesis and detailed SAR of this class of compounds are reported.
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