Direct Synthesis of 2,3-Diaroyl Quinolines and Pyridazino[4,5-b]quinolines via an I2-Promoted One-Pot Multicomponent Reaction

The first synthesis of 2,3-diaroyl quinolines via a formal [3 + 2 + 1] cycloaddition of enaminones, aryl methyl ketones, and aryl amines is disclosed. This reaction efficiently affords a 1,4-dicarbonyl scaffold, which is a useful building block for constructing complex fused heterocycles. Furthermore, the 1,4-dicarbonyl scaffold has been used directly to prepare pyridazino[4,5-b]quinoline skeletons in one-pot.