Microbial transformation of curcumol by Cunninghamella blakesleana.

Microbial transformation of curcumol (1) by Cunninghamella blakesleana (AS 3.970) yielded six metabolites. On the basis of spectral data, their structures were elucidated as 14-hydroxy-9E curcumol (2), 10R,14-dihydroxy curcumol (3), 10S,14-epoxy curcumol (4), 10R,14-epoxy curcumol (5), 10S,14-epoxy-7,11-dehydrocurcumol (6), 10R,14-epoxy-7,11-dehydrocurcumol (7), respectively. Among them 2, 3, 6 and 7 are new compounds; 4 and 5, 6 and 7 are two pairs of epimers.