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VEGF antagonists formulations

2006 
A liquid formulation of a VEGF antagonist, comprising 10 mM histidine, 50 mM NaCI, 5-20% sucrose, and 50-100 mg / ml of a fusion protein having a receptor component consisting of a similar domain immunoglobulin (Ig) 2 of a first VEGF receptor and Ig domain 3 of a second VEGF receptor component and a multimerizing, at pH 6.0-6.5, wherein the first VEGF receptor is Flt1 and the second VEGF receptor is Flk1 or of Flt4, further comprising polysorbate 20 0.1% or 3% PEG 3350.
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