SELECTIVE ANTAGONISTS huTNFR1.

A li gando lh uTNFR1 qu e com lights a co NSTRUCTION protein c on (i) one or m ore s ecuencias amino acid of human origin capable of reducing the immunogenic response of said ligand huTNFR1 in humans, and (ii) one or more amino acid sequences capable of selectively binding to huTNFR1 form non-human origin, where the construction of proteins comprises the amino acid sequence according to SEQ. ID. No. 7 as domin Variable io heavy chain (VH ) and the amino acid sequence according to SEQ. ID. No. 8 com or variable domain of the light chain (VL), or a nto Fragme of a humanized antibody, the fragment being a scFv comprising the amino acid sequence of according to SEQ. ID. No. 9.