Dentin hypersensitivity reduction of a new toothpaste containing 8.0% arginine and 1450 ppm fluoride: an 8-week clinical study on Chinese adults.

Purpose: To present the results of an 8-week dentin hypersensitivity clinical study in which the efficacy of a new Pro-Argin formula toothpaste, with gentle whitening benefits, containing 8.0% arginine, a high cleaning calcium carbonate system, and 1450 ppm fluoride as sodium monofluorophosphate (MFP) was compared to that of a commercial Pro-Argin formula toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride as MFP and a negative control toothpaste containing calcium carbonate and 1450 ppm fluoride as MFP. Methods: An 8-week clinical study, with 121 subjects, was conducted in Chengdu, Sichuan, China, using a double-blind, stratified, threetreatment design. Tactile and air blast sensitivity assessments were used to compare the efficacy of the three products. Results: This clinical study demonstrated that the new Pro-Argin formula toothpaste provided a significant reduction in dentin hypersensitivity when used over a period of 8 weeks. The study also showed that the new toothpaste provided significantly greater reductions (P< 0.05) in dentin hypersensitivity in response to tactile (64.4%, 71.1%, and 61.0%) and air blast (40.7%, 58.8.0%, and 74.4%) stimuli than the negative control toothpaste containing 1450 ppm fluoride after 2, 4, and 8 weeks of product use, respectively. The results for the new toothpaste did not differ significantly from those of the positive control toothpaste at all time points in the study. (Am J Dent 2010;23 Sp Is A:28A-35A). CLINICAL SIGNIFICANCE: A new Pro-Argin formula toothpaste with whitening benefits, containing 8.0% arginine, a high cleaning calcium carbonate system, and 1450 ppm fluoride, provides significantly greater dentin hypersensitivity relief (P< 0.05) compared to a negative control toothpaste after 2, 4, and 8 weeks of product use. It provides hypersensitivity relief that is not statistically significantly different than the positive control Pro-Argin formula toothpaste after 2, 4, and 8 weeks of product use. : Dr. Fotinos S. Panagakos, Colgate-Palmolive Technology Center, 901 River Road, Piscataway, NJ 08854, USA. E: foti_panagakos@colpal.com