Synthesis and In Vitro Antimicrobial Screening of New Azetidin-2-ones of 5-Ethyl Pyridine-2-ethanol

A new series of azetidinones is described in this paper; Schiff base (4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j, 4k, 4l, 4m, 4n, 4o) were synthesized from 4-[2-(5-ethylpyridin-2-yl)ethoxy]benzaldehyde, which was used to synthesize azetidinones (5a, 5b, 5c, 5d, 5e, 5f, 5g, 5h, 5i, 5j, 5k, 5l, 5m, 5n, 5o), (6a, 6b, 6c, 6d, 6e, 6f, 6g, 6h, 6i, 6j, 6k, 6l, 6m, 6n, 6o), and (7a, 7b, 7c, 7d, 7e, 7f, 7g, 7h, 7i, 7j, 7k, 7l, 7m, 7n, 7o). The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR, and 13C NMR spectral data. All the products were screened against different strains of bacteria and fungi. Most of the monosubstituted and disubstituted chloro groups are more effective to both bacterial and fungal species in comparison with the standard drugs.