Gold vs Rhodium Catalysis: Tuning Reactivity Through Catalyst Control in the C-H Alkynylation of Isoquinolones.
2016
A site-selective C-4/C-8 alkynylation of isoquinolones catalyzed by gold and rhodium complexes is reported. A broad range of synthetically useful functional groups (-F, -Cl, -Br, -CF3, -OMe, alkyl, etc.) were tolerated, providing an efficient and robust protocol for the synthesis either C-4- or C-8-alkynylated isoquinolones.
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