The D9N, N291S and S447X variants in the lipoprotein lipase (LPL) gene are not associated with Type III Hyperlipidemia

Background Type III hyperlipidemia (Type III HLP) is associated with homozygosity for the e2 allele of the APOE gene. However only about 10% of e2 homozygotes develop Type III HLP and it is assumed that additional genetic and/or environmental factors are required for its development. Common variants in the LPL gene have been proposed as likely genetic co-factors.