L'analyse SDS-PAGE des protéines et antigènes de surface révèle une forte hétérogénéité chez les clones naturels de Trypanosoma cruzi, corrélée à la variabilité isoenzymatique

Sirifcice protein arid siirface aiiiigeii pailerns of' 19 Trypanosoma cruzi Iaboraiory clones, rcpesentitig 17 different isozyniic profles (zvmoclenzes), were compared by SDS- PAC E analysis. Sirtjhce proiein pairerris were foirnd io be corriples cirid Iiererogareoirs. According to ilie niimber of coninioti bcind.s, ive ccilcirlated sinzilariiy coel-jicienu of s1irfiice protein patterns 011 /lie one hard, and of siiflace antigen pciiterns on /he oilier hand? for 33 siock pairwise coniparisons. (ti burli cases, these caefjicienis were statisiicully correlated io the isozyme iticles o/' getieiic identi1y. Siich a correlation between itidepenclent genetic nzarkers fnsoiirs tlie clonal siriicitire of T. cruzi naiirral popiilations prerioiislv eoideticetl (I). Moreooer, we did mi obserse ciny noiahle cl(t"erence.s in he suiface antigen prirtern among 4 T. cruzi cloned stacks precipitnted by Iioniologoiis cis ireIl (is heierologoirs liyperin~nzirtze sera. The irnniioiologicril signiJkince of the n?olecirl(ir weiglii nciriubiliry in sitifi-lce ariiigen patterns among dqferetit zyniodenies is cli.sciis.secl.