The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages

Yunlong Yang,Patrik Andersson,Kayoko Hosaka,Yin Zhang,Renhai Cao,Hideki Iwamoto,Xiaojuan Yang,Masaki Nakamura,Jian Wang,Rujie Zhuang,Hiromasa Morikawa,Yuan Xue,Harald Braun,Rudi Beyaert,Nilesh J. Samani,Susumu Nakae,Emily Hams,Steen Dissing,Padraic G. Fallon,Robert Langer,Yihai Cao

The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages

2016

Signalling molecules and pathways that mediate crosstalk between various tumour cellular compartments in cancer metastasis remain largely unknown. We report a mechanism of the interaction between p ...

Keywords:

Molecular biology
Interleukin 33
Inflammation
Angiogenesis
Stromal cell
Cancer
Immunology
Cancer research
Metastasis
Growth factor receptor
Platelet-derived growth factor receptor
Biology

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