Down‐Regulation of Replication Factor C‐40 (RFC40) causes chromosomal missegregation in neonatal and hypertrophic adult rat cardiac myocytes
2012
Background
Adult mammalian cardiac myocytes are generally assumed to be terminally differentiated; nonetheless, a small fraction of cardiac myocytes have been shown to replicate during ventricular remodeling. However, the expression of Replication Factor C (RFC; RFC140/40/38/37/36) and DNA polymerase δ (Pol δ) proteins, which are required for DNA synthesis and cell proliferation, in the adult normal and hypertrophied hearts has been rarely studied.
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