1-Benzylbenzimidazoles: The discovery of a novel series of bradykinin B 1 receptor antagonists

The design, synthesis, and structure-activity studies of a novel series of BK B 1 receptor antagonists based on a 1-benzylbenzimidazole chemotype are described. A number of compounds, for example, 38g, with excellent affinity for the cynomolgus macaque and rat bradykinin B 1 receptor were discovered.