Studies on chemical constituents of Guizhi Fuling Capsule (IV)

Objective To investigate the chemical constituents from the petroleum ether and ethyl acetate extract of Guizhi Fuling Capsule(GFC).Methods The compounds were separated with chromatography on silica gel and polydextran gel columns,and prep-HPLC,and their chemical structures were identified by NMR and MS spectral methods,respectively.Results Eight compounds were isolated from the petroleun ether extract and were identified as coumarin(1),7-hydroxycoumarin(2),cinnamic alcohol(3),ergosterol(4),ergosta-4,6,8(14),22-tetraen-3-one(5),β-amyrin acetate(6),campesterol(7),and α-amyrin acetate(8).Thirteen compounds were isolated from the ethyl acetate extract and were identified as apingenin(9),kaemferol(10),quercetin(11),kaempferol-3-O-glucopyranoside(12),catechin(13),epicatechin(14),syringic acid(15),hyperin(16),eicosanoids(17),syringaresinol(18),mudanpioside A(19),mudanpioside C(20),and galloylpaeoniflorin(21).Conclusion Compounds 1—21 are isolated from GFC for the first time.