Negative correlation between right prefrontal activity during response inhibition and impulsiveness: A fMRI study
2004
Behavioral disinhibition in Go/No–Go task
is thought to be associated with impulsiveness in humans.
Recent imaging studies showed that neural circuits
involving diverse areas of the frontal cortex and
other association cortex sites such as the parietal cortex
are implicated in the inhibition of response during No–Go trials. The aim of the present study was to investigate
the association between regional cerebral activation
during No–Go trials and impulsiveness. Seventeen righthanded
healthy volunteers participated in the study. We
used functional magnetic resonance imaging to measure
the brain activation during a Go/No–Go task. The
Barratt Impulsiveness Scale, 11th version (BIS–11) was
used to measure impulsiveness. Activated regions included
the right middle frontal gyrus and the inferior
parietal lobe, which is consistent with previous neuroimaging
studies. A negative correlation was observed
between the motor impulsiveness of BIS–11 and No–Gorelated
activation in the right dorsolateral prefrontal
cortex (RDLPFC). Our results suggest that the RDLPFC
is the area most sensitive to differences in individual
motor impulsiveness and its activity may be an indicator
of the individual capacity for response inhibition.
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