Quantitative Structure-Activity Relationships Analysis, Homology modeling, Docking and Molecular Dynamics studies of triterpenoid saponins as Kirsten Rat Sarcoma Inhibitors.

AbstractOncogenic Kirsten RAt Sarcoma (KRAS) mutations are attractive targets in non-small-cell lung cancer (NSCLC). Thus, the objective of this work is to discover promising inhibitors that target...