Multiple regulatory variants located in cell type-specific enhancers within the PKP2 locus form major risk and protective haplotypes for canine atopic dermatitis in German shepherd dogs

Katarina Tengvall,Sergey V. Kozyrev,Marcin Kierczak,Kerstin Bergvall,Fabiana H. G. Farias,Brita Ardesjö-Lundgren,Mia Olsson,Eva Murén,Ragnvi Hagman,Tosso Leeb,Gerli Pielberg,Åke Hedhammar,Göran Andersson,Kerstin Lindblad-Toh

Multiple regulatory variants located in cell type-specific enhancers within the PKP2 locus form major risk and protective haplotypes for canine atopic dermatitis in German shepherd dogs

2016

Katarina Tengvall
Sergey V. Kozyrev
Marcin Kierczak
Kerstin Bergvall
Fabiana H. G. Farias
Brita Ardesjö-Lundgren
Mia Olsson
Eva Murén
Ragnvi Hagman
Tosso Leeb
Gerli Pielberg
Åke Hedhammar
Göran Andersson
Kerstin Lindblad-Toh

Background: Canine atopic dermatitis (CAD) is a chronic inflammatory skin disease triggered by allergic reactions involving IgE antibodies directed towards environmental allergens. We previously id ...

Keywords:

Genetics
Genetic association
Inflammatory skin disease
Haplotype
Locus (genetics)
Enhancer
Cell type
Immunoglobulin E
Biology
Immunology
Atopic dermatitis
type specific

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