IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

Claudia A. Nold-Petry,Camden Y. Lo,Ina Rudloff,Kirstin Elgass,Suzhao Li,Michael P. Gantier,Amelie S. Lotz-Havla,Søren W. Gersting,Steven X. Cho,Jason C. Lao,Andrew M. Ellisdon,Bjorn Rotter,Tania Azam,Niamh E. Mangan,Fernando J. Rossello,James C. Whisstock,Philip Bufler,Cecilia Garlanda,Alberto Mantovani,Charles A. Dinarello,Marcel F. Nold

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

2015

IL-37 is a member of the IL-1 family with profound anti-inflammatory functions. Nold and colleagues identify the receptor for IL-37 and clarify the molecular nature of the anti-inflammatory pathway induced by this cytokine.

Keywords:

Immunology
Cell biology
Biology
Anti-inflammatory
Cytokine
Signal transduction
Receptor
Immunity
Cell culture
Regulation of gene expression
Transgene
C-Mer Tyrosine Kinase

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