Michler's ethylketone as a novel negative-ion matrix for the enhancement of lipid MALDI tissue imaging
2021
Michler's ethylketone (MEK, 4,4’-bis(diethylamino)benzophenone), commonly-known as an intermediate in the synthesis of dyes and pigments, was successfully screened and optimized as a novel matrix for the enhancement of lipid in situ detection and imaging in tissues by MALDI-MSI. The results show several properties of MEK as a powerful MALDI matrix, including strong UV absorption, μm-sized crystals and uniform matrix-coating, super high vacuum chemical stability, low matrix-related ion interference, super soft ionization, as well as high lipid ionization efficiency.
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