Chemogenomics : methods and applications

1. Organizing Bioactive Compound Discovery in Target Families H. Peter Nestler 2. Compound Library Design for Target Families K. V. Balakin, Y. A. Ivanenkov, and N. P. Savchuk 3. Targeting the Purinome Jeremy M. Murray and Dirksen E. Bussiere 4. Cofactor Chemogenomics Ratna Singh and Andrea Mozzarelli 5. Chemogenomics with Protein Secondary Structure Mimetics Garland R. Marshall, Daniel J. Kuster, and Ye Che 6. Database Systems for Knowledge-Based Discovery Sarma A.R.P. Jagarlapudi and Radha Kishan K.V. 7. Knowledge-Based Virtual Screening: Application to the MDM4/p53 Protein-Protein Interaction Edgar Jacoby, Andreas Boettcher, Lorenz M. Mayr, Nathan Brown, Jeremy L. Jenkins, Joerg Kallen, Caroline Engeloch, Ulrich Schopfer, Pascal Furet, Keiichi Masuya, and Joanna Lisztwan 8. Off-Target Networks Derived from Ligand Set Similarity Michael J. Keiser and Jerome Hert 9. Chemogenomic Analysis of Safety Profiling Data Josef Scheiber and Jeremy L. Jenkins 10. Network and Pathway Analysis of Compound-Protein Interactions Richard J. Brennan and Svetlana Bureeva 11. The Flexible Pocketome Engine for Structural Chemogenomics Ruben Abagyan and Irina Kufareva 12. Structure-Based Chemogenomics: Analysis of Protein Family Landscapes Bernard Pirard 13. Hypothesis-Driven Screening Ulrich Schopfer, Caroline Engeloch, Frank Hohn, Herve Mees, Jennifer Leeds, Fraser Glickman, Gunther Scheel, Sandrine Ferrand, Peter Fekkes, and Martin Pfeifer