Toxicokinetics and bioaccumulation characteristics of bisphenol analogues in common carp (Cyprinus carpio)

Abstract Toxicokinetics and bioconcentration of eight common bisphenol analogues, including bisphenol A (BPA), -B, –C, -E, –S, -Z, -AF, and -AP in common carp (Cyprinus carpio) were investigated. Both free (BPfree) and total forms (BPtotal) of the bisphenols were measured in various fish tissues. The conjugated forms of bisphenols were calculated based on BPfree and BPtotal. The calculated bioconcentration factors (BCFs) based on the total bisphenols (BPtotal) in the carp whole body were in the range of 0.3–320, agreeing with previous field results from Taihu Lake, China. The elimination rate constant (ke) positively correlated with the fraction of conjugated form (fconjugated), which displayed negative correlation with their log Kow (r = −0.861, p   liver ≫ muscle. The uptake rate constants (ku) in kidney (r = 0.836, p